The Isabelle Royale Hotel & Suites is located in the heart of Makati City, which is Manila's business district. Guests will find many upscale shops and restaurants in the area, as well as other places of interest like the Ayala Museum, Greenbelt Park, the Enchanted Kingdom, the Manila Stock Exchange, the Ayala Center, and the Cultural Center for the Philippines. The Isabelle Royale Hotel & Suites is located just a short drive from the airport. Buses and shuttles are available for travel between the two. Guests will find that many places of interest are within walking distance from the hotel, and taxis or rental cars can be easily arranged with the front desk.

Every room at the Isabelle Royale Hotel & Suites is designed with comfort in mind. Guests will enjoy the full kitchens with refrigerators, microwaves, cooktops, and utensils. Other amenities include coffee and tea machines, premium bedding, work desks, Internet access, balconies, and en suite baths with hair dryers and bath supplies.

There are many amenities available, including massage services, laundry and dry cleaning assistance, a hotel safe, currency exchange, and a twenty-four hour staff. Business travelers will find plenty of meeting space, wireless Internet connections, and access to office equipment.